Detection of acquired TERT amplification in addition to predisposing p53 and Rb pathways alterations in EGFR-mutant lung adenocarcinomas transformed into small-cell lung cancers.

doi:10.1016/j.lungcan.2022.01.008

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Detection of acquired TERT amplification in addition to predisposing p53 and Rb pathways alterations in EGFR-mutant lung adenocarcinomas transformed into small-cell lung cancers.

Lung cancer (Amsterdam, Netherlands) - 1 May 2022

Mc Leer Anne, Foll Matthieu, Brevet Marie, Antoine Martine, Novello Silvia, Mondet Julie, Cadranel Jacques, Girard Nicolas, Giaj Levra Matteo, Demontrond Pierre, Audigier-Valette Clarisse, Letouzé Eric, Lantuéjoul Sylvie, Fernandez-Cuesta Lynnette, Moro-Sibilot Denis

Abstract excerpt

INTRODUCTION: Among the different mechanisms of acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) reported in EGFR-mutated lung adenocarcinoma (EGFR-LUAD) patients, histological transformation into small cell carcinoma (SCLC) occurs in 3-14% of resistant cases, regardless of the generation of EGFR-TKI. In recent studies, bi-allelic inactivation of TP53 and RB1 has been identified in a vast majority of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Small Cell

Share to Drug Resistance, Neoplasm

Share to ErbB Receptors

Share to Protein Kinase Inhibitors

Share to Retinoblastoma Protein

Share to Small Cell Lung Carcinoma

Share to Telomerase

Source

Open in PubMed

Identifiers

PMID: 35183375
DOI: 10.1016/j.lungcan.2022.01.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of acquired TERT amplification in addition to predisposing p53 and Rb pathways alterations in EGFR-mutant lung adenocarcinomas transformed into small-cell lung cancers.PMID 35183375Read ↗

Rare transformation from lung adenocarcinoma to sarcomatoid carcinoma mediates resistance to inhibitors targeting different driver oncogenesSemantic proximity Read ↗

Genome-wide profiling of non-smoking-related lung cancer cells reveals common RB1 rearrangements associated with histopathologic transformation in EGFR-mutant tumors.Semantic proximity Read ↗

Small Cell Lung Cancer Transformation following Treatment in EGFR-Mutated Non-Small Cell Lung CancerSemantic proximity Read ↗

Case report: TP53 and RB1 loss may facilitate the transformation from lung adenocarcinoma to small cell lung cancer by expressing neuroendocrine markersSemantic proximity Read ↗

Transformation or tumor heterogeneity: Mutations in EGFR, SOX2, TP53, and RB1 persist in the histological rapid conversion from lung adenocarcinoma to small-cell lung cancer.Semantic proximity Read ↗

Clinicopathological and molecular features of non-small cell lung cancer without TKI therapy that transforms into small-cell lung cancerSemantic proximity Read ↗

Genotyping of RB1 status identifies two distinct subtypes in EGFR ‐mutant lung cancers with SCLC transformationSemantic proximity Read ↗

Expression of EGFR-mutant proteins and genomic evolution in EGFR-mutant transformed small cell lung cancerSemantic proximity Read ↗

Brief Report: Comprehensive Clinicogenomic Profiling of Small Cell Transformation From EGFR-Mutant NSCLC Informs Potential Therapeutic TargetsSemantic proximity Read ↗

Comprehensive molecular and clinical insights into non-small cell lung cancer transformation to small cell lung cancer with an illustrative case report.Semantic proximity Read ↗

Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung AdenocarcinomasSemantic proximity Read ↗

Histologic transformation of non-small-cell lung cancer in response to tyrosine kinase inhibitors: Current knowledge of genetic changes and molecular mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.