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Article

Clinical Impact of Next-Generation Sequencing Multi-Gene Panel Highlighting the Landscape of Germline Alterations in Ovarian Cancer Patients.

International journal of molecular sciences - 13 Dec 2022

Gurioli Giorgia, Tedaldi Gianluca, Farolfi Alberto, Petracci Elisabetta, Casanova Claudia, Comerci Giuseppe, Danesi Rita, Arcangeli Valentina, Ravegnani Mila, Calistri Daniele, Zampiga Valentina, Cangini Ilaria, Fonzi Eugenio, Virga Alessandra, Tassinari Davide, Rosati Marta, Ulivi Paola, De Giorgi Ugo

Abstract excerpt

BRCA1 and BRCA2 are the most frequently mutated genes in ovarian cancer (OC) crucial both for the identification of cancer predisposition and therapeutic choices. However, germline variants in other genes could be involved in OC susceptibility. We characterized OC patients to detect mutations in genes other than BRCA1/2 that could be associated with a high risk of developing OC and permit patients to enter the...

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Identifiers

PMID: 36555431
DOI: 10.3390/ijms232415789
PMCID: PMC9779064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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