APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.

doi:10.1038/jcbfm.2015.85

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Article

APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jan 2016

Gesierich Benno, Opherk Christian, Rosand Jonathan, Gonik Mariya, Malik Rainer, Jouvent Eric, Hervé Dominique, Adib-Samii Poneh, Bevan Steve, Pianese Luigi, Silvestri Serena, Dotti Maria T, De Stefano Nicola, van der Grond Jeroen, Boon Elles M J, Pescini Francesca, Rost Natalia, Pantoni Leonardo, Oberstein Saskia A Lesnik, Federico Antonio, Ragno Michele, Markus Hugh S, Tournier-Lasserve Elisabeth, Chabriat Hugues, Dichgans Martin, Duering Marco, Ewers Michael

Abstract excerpt

Apolipoprotein E (APOE) increases the risk for Alzheimer’s disease (ɛ4 allele) and cerebral amyloid angiopathy (ɛ2 and ɛ4), but its role in small vessel disease (SVD) is debated. Here we studied the effects of APOE on white matter hyperintensity volume (WMHV) in CADASIL (cerebral autosomal domina...

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Identifiers

PMID: 25920955
DOI: 10.1038/jcbfm.2015.85
PMCID: PMC4758562

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25920955-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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