Article
A comparative multi-parametric in vitro model identifies the power of test conditions to predict the fibrotic tendency of a biomaterial.
Scientific reports - 10 May 2017
Jannasch Maren, Gaetzner Sabine, Weigel Tobias, Walles Heike, Schmitz Tobias, Hansmann Jan
Abstract excerpt
Despite growing effort to advance materials towards a low fibrotic progression, all implants elicit adverse tissue responses. Pre-clinical biomaterial assessment relies on animals testing, which can be complemented by in vitro tests to address the Russell and Burch's 3R aspect of reducing animal burden. However, a poor correlation between in vitro and in vivo biomaterial assessments confirms a need for suitable...
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