Authors' Response to Comment on "When Genes Meet Gels: Computational Immunogenetics of Dermal Fillers and Stratified Risk of Immune and Fibrotic Reactions Across Compositions and Genotypes".

Abstract excerpt

We thank the correspondents for their thoughtful commentary on our recently published computational framework evaluating immune and fibrotic risk associated with dermal filler materials. We clarify that the proposed model was intentionally designed to generate relative, rank-based risk indices rather than absolute clinical event probabilities, a distinction explicitly acknowledged in the original manuscript. Key...

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