Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of Premalignant Disease.

Cold Spring Harbor perspectives in medicine - 1 Dec 2017

Curtius Kit, Wright Nicholas A, Graham Trevor A

Abstract excerpt

Where does cancer come from? Although the cell-of-origin is difficult to pinpoint, cancer clones harbor information about their clonal ancestries. In an effort to find cells before they evolve into a life-threatening cancer, physicians currently diagnose premalignant diseases at frequencies that substantially exceed those of clinical cancers. Cancer risk prediction relies on our ability to distinguish between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Cell Transformation, Neoplastic
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Precancerous Conditions

Source

Open in PubMed Open full text

Identifiers

PMID: 28490542
DOI: 10.1101/cshperspect.a026542
PMCID: PMC5710095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of Premalignant Disease.PMID 28490542Read ↗

The Long Evolutionary Journey of Cancer from Ancestor to Modern Humans.Semantic proximity Read ↗

Return of de-differentiation: why cancer is a developmental disease.Semantic proximity Read ↗

Cancers make their own luck: theories of cancer origins.Semantic proximity Read ↗

Introduction to Evolutionary Cancer Cell Biology (Eccb) and Ancestral Cancer GenomicsSemantic proximity Read ↗

Introduction to Evolutionary Cancer Cell Biology (ECCB) and Ancestral Cancer GenomicsSemantic proximity Read ↗

Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical ImplicationsSemantic proximity Read ↗

Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies.Semantic proximity Read ↗

Cancer evolution: from Darwin to the Extended Evolutionary SynthesisSemantic proximity Read ↗

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations.Semantic proximity Read ↗

Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid modelsSemantic proximity Read ↗

Preventive Evolutionary Medicine of CancersSemantic proximity Read ↗

Insights into clonal hematopoiesis and its relation to cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.