Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Return of de-differentiation: why cancer is a developmental disease.

Current opinion in oncology - 1 Jan 2001

da Costa L F

Abstract excerpt

Many important advances have been made in the phenotypic and genetic characterization of malignant tumors since the publication of Peter Nowell's seminal article on the origin of cancer, but there has been no consistent effort to incorporate this wealth of knowledge into a general model of carcinogenesis. Current theoretical discussions on cancer are frequently dominated by attempts to categorize genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Cell Differentiation
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Models, Theoretical

Share to Neoplasms

Share to Phenotype

Source

Identifiers

PMID: 11148688
DOI: 10.1097/00001622-200101000-00012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Return of de-differentiation: why cancer is a developmental disease.PMID 11148688Read ↗

Evolution of Premalignant Disease.Semantic proximity Read ↗

Neo-Darwinian Principles Exemplified in Cancer Genomics.Semantic proximity Read ↗

Cancers make their own luck: theories of cancer origins.Semantic proximity Read ↗

The Long Evolutionary Journey of Cancer from Ancestor to Modern Humans.Semantic proximity Read ↗

The Carcinogenic Chimera Cell Hypothesis: How Ectopic Expression of Cancer-Related Genes Leads to CancerSemantic proximity Read ↗

Introduction to Evolutionary Cancer Cell Biology (Eccb) and Ancestral Cancer GenomicsSemantic proximity Read ↗

Cancer evolution: from Darwin to the Extended Evolutionary SynthesisSemantic proximity Read ↗

Evolutionary, Non-Mutational Cancers Cannot Be Considered AtavisticSemantic proximity Read ↗

Cancer development and progression: a non-adaptive process driven by genetic drift.Semantic proximity Read ↗

Introduction to Evolutionary Cancer Cell Biology (ECCB) and Ancestral Cancer GenomicsSemantic proximity Read ↗

Theories of cancer origin.Semantic proximity Read ↗

Tracing the path of cancer initiation: the AA protein-based model for cancer genesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.