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Article

Developmental exposure to estrogen alters differentiation and epigenetic programming in a human fetal prostate xenograft model.

PloS one - 1 Jan 2015

Saffarini Camelia M, McDonnell-Clark Elizabeth V, Amin Ali, Huse Susan M, Boekelheide Kim

Abstract excerpt

Prostate cancer is the most frequent non-cutaneous malignancy in men. There is strong evidence in rodents that neonatal estrogen exposure plays a role in the development of this disease. However, there is little information regarding the effects of estrogen in human fetal prostate tissue. This study explored early life estrogen exposure, with and without a secondary estrogen and testosterone treatment in a human...

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Identifiers

PMID: 25799167
DOI: 10.1371/journal.pone.0122290
PMCID: PMC4370592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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