Article
Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression.
Scientific reports - 8 May 2017
Kazantseva Marina, Hung Noelyn A, Mehta Sunali, Roth Imogen, Eiholzer Ramona, Rich Alison M, Seo Benedict, Baird Margaret A, Braithwaite Antony W, Slatter Tania L
Abstract excerpt
Accumulating evidence suggests tumor protein 53 (p53) promotes correct cellular differentiation. Thus, mutant TP53 may be more frequent in tumors with irregular differentiation. This study investigated whether TP53 mutations were more frequent in diffuse large B cell lymphoma (DLBCL) that lacked the B cell lineage marker CD19. Sixteen CD19 negative and 78 CD19 positive DLBCL were sequenced for TP53 mutations....
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