Article
Genetic alterations crossing the borders of distinct hematopoetic lineages and solid tumors: Diagnostic challenges in the era of high-throughput sequencing in hemato-oncology.
Critical reviews in oncology/hematology - 1 Jun 2018
Shumilov Evgenii, Flach Johanna, Pabst Thomas, Fiedler Martin, Angelillo-Scherrer Anne, Trümper Lorenz, Joncourt Raphael, Kohlmann Alexander, Bacher Ulrike
Abstract excerpt
Owing to the introduction of next-generation sequencing (NGS) new challenges for diagnostic algorithms and the interpretation of the results for therapeutic decision making in hemato-oncology have arisen. Recurrent somatic mutations crossing the borders between different hematological entities and solid neoplasms have been detected. In analogy to mutant TP53, the same mutation type may occur in myeloid, B- or...
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