Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.

Nature cell biology - 1 Aug 2017

Zhou Bo O, Yu Hua, Yue Rui, Zhao Zhiyu, Rios Jonathan J, Naveiras Olaia, Morrison Sean J

Abstract excerpt

Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes synthesize SCF. They arise from Adipoq-Cre/ER+ progenitors, which represent ∼5% of LepR+ cells, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adiponectin
Share to Paracrine Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Leptin

Share to Regeneration

Share to Stem Cell Factor

Share to Stem Cell Niche

Share to Whole-Body Irradiation

Source

Open in PubMed Open full text

Identifiers

PMID: 28714970
DOI: 10.1038/ncb3570
PMCID: PMC5536858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.PMID 28714970Read ↗

Bone marrow adipocytes promote hematopoietic regeneration by secreting SCFSemantic proximity Read ↗

Endothelial and perivascular cells maintain haematopoietic stem cells.Semantic proximity Read ↗

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environmentSemantic proximity Read ↗

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environmentSemantic proximity Read ↗

A novel skeletal-specific adipogenesis pathway defines key origins and adaptations of bone marrow adipocytes with age and diseaseSemantic proximity Read ↗

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone MarrowSemantic proximity Read ↗

Adipose Tissue-Derived Mesenchymal Stem Cells Facilitate Hematopoiesis in Vitro and in VivoSemantic proximity Read ↗

Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammationSemantic proximity Read ↗

Bone marrow adiposity and the hematopoietic niche: A historical perspective of reciprocity, heterogeneity, and lineage commitmentSemantic proximity Read ↗

Regional specialization and fate specification of bone stromal cells in skeletal developmentSemantic proximity Read ↗

Marrow adipogenic lineage precursors (MALPs) facilitate bone marrow recovery after chemotherapySemantic proximity Read ↗

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.