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Article

The influence of rAAV2-mediated SOX2 delivery into neonatal and adult human RPE cells; a comparative study.

Journal of cellular physiology - 1 Feb 2018

Ezati Razie, Etemadzadeh Azadeh, Soheili Zahra-Soheila, Samiei Shahram, Ranaei Pirmardan Ehsan, Davari Malihe, Najafabadi Hoda Shams

Abstract excerpt

Cell replacement is a promising therapy for degenerative diseases like age-related macular degeneration (AMD). Since the human retina lacks regeneration capacity, much attention has been directed toward persuading for cells that can differentiate into retinal neurons. In this report, we have investigated reprogramming of the human RPE cells and concerned the effect of donor age on the cellular fate as a critical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28480968
DOI: 10.1002/jcp.25991

Genes

RPE
SOX2
PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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