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Article

AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells.

International journal of molecular sciences - 3 Feb 2020

Garita-Hernandez Marcela, Routet Fiona, Guibbal Laure, Khabou Hanen, Toualbi Lyes, Riancho Luisa, Reichman Sacha, Duebel Jens, Sahel Jose-Alain, Goureau Olivier, Dalkara Deniz

Abstract excerpt

Human induced pluripotent stem cells (hiPSCs) promise a great number of future applications to investigate retinal development, pathophysiology and cell therapies for retinal degenerative diseases. Specific approaches to genetically modulate hiPSC would be valuable for all of these applications. Vectors based on adeno-associated virus (AAV) have shown the ability for gene delivery to retinal organoids derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32028585
DOI: 10.3390/ijms21030994
PMCID: PMC7036814

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