Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic.

Free radical biology & medicine - 1 Jul 2017

Gruhlke Martin C H, Schlembach Ivan, Leontiev Roman, Uebachs Andreas, Gollwitzer Peter U G, Weiss Alexander, Delaunay Agnes, Toledano Michel, Slusarenko Alan J

Abstract excerpt

Allicin is a thiol-reactive sulfur-containing natural product from garlic with a broad range of antimicrobial effects against prokaryotes and eukaryotes. Previous work showed that the S. cerevisiae OSI1 gene is highly induced by allicin and other thiol-reactive compounds, and in silico analysis revealed multiple Yap1p binding motifs in the OSI1 promoter sequence. An OSI1-promoter::luciferase reporter construct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Cysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disulfides

Share to Gene Expression Regulation, Fungal

Share to Oxidants

Share to Oxidation-Reduction

Share to Oxidoreductases

Share to Transcriptional Activation

Source

Identifiers

PMID: 28479370
DOI: 10.1016/j.freeradbiomed.2017.05.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic.PMID 28479370Read ↗

Yippee-like protein Moh1 links gene expression to metabolism and selective stress resistance in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Activity of the Yap1 transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis.Semantic proximity Read ↗

Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation.Semantic proximity Read ↗

A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism.Semantic proximity Read ↗

Glutathione, but not transcription factor Yap1, is required for carbon source-dependent resistance to oxidative stress in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae.Semantic proximity Read ↗

Molecular mechanism of oxidative stress perception by the Orp1 protein.Semantic proximity Read ↗

Msn2p/Msn4p act as a key transcriptional activator of yeast cytoplasmic thiol peroxidase II.Semantic proximity Read ↗

Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide.Semantic proximity Read ↗

Yap1: a DNA damage responder in Saccharomyces cerevisiae.Semantic proximity Read ↗

Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.