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Article

The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency.

Cell chemical biology - 22 Jun 2017

Bowman Caitlyn E, Rodriguez Susana, Selen Alpergin Ebru S, Acoba Michelle G, Zhao Liang, Hartung Thomas, Claypool Steven M, Watkins Paul A, Wolfgang Michael J

Abstract excerpt

Malonyl-coenzyme A (malonyl-CoA) is a central metabolite in mammalian fatty acid biochemistry generated and utilized in the cytoplasm; however, little is known about noncanonical organelle-specific malonyl-CoA metabolism. Intramitochondrial malonyl-CoA is generated by a malonyl-CoA synthetase, ACSF3, which produces malonyl-CoA from malonate, an endogenous competitive inhibitor of succinate dehydrogenase. To...

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Identifiers

PMID: 28479296
DOI: 10.1016/j.chembiol.2017.04.009
PMCID: PMC5482780

Genes

ACSF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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