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Article

Disruption of NHE8 expression impairs Leydig cell function in the testes.

American journal of physiology. Cell physiology - 15 Feb 2015

Xu Hua, Chen Huacong, Li Jing, Zhao Yang, Ghishan Fayez K

Abstract excerpt

Multiple sodium/hydrogen exchanger (NHE) isoforms are expressed in the testes, and they play various roles in cell volume regulation, intracellular pH regulation, and fluid absorption. NHE8, the most recently characterized NHE family member, is detected in the Leydig cells in humans and mice in great abundance by immunohistochemistry in the current study. Male mice lacking NHE8 expression were infertile. Despite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25472965
DOI: 10.1152/ajpcell.00289.2014
PMCID: PMC4329425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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