Article
Genome-wide association studies for complex traits: consensus, uncertainty and challenges.
Nature reviews. Genetics - 1 May 2008
McCarthy Mark I, Abecasis Gonçalo R, Cardon Lon R, Goldstein David B, Little Julian, Ioannidis John P A, Hirschhorn Joel N
Abstract excerpt
The past year has witnessed substantial advances in understanding the genetic basis of many common phenotypes of biomedical importance. These advances have been the result of systematic, well-powered, genome-wide surveys exploring the relationships between common sequence variation and disease predisposition. This approach has revealed over 50 disease-susceptibility loci and has provided insights into the allelic...
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