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Article

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.

Cancer discovery - 1 Aug 2017

Gu Yi-Feng, Cohn Shannon, Christie Alana, McKenzie Tiffani, Wolff Nicholas, Do Quyen N, Madhuranthakam Ananth J, Pedrosa Ivan, Wang Tao, Dey Anwesha, Busslinger Meinrad, Xie Xian-Jin, Hammer Robert E, McKay Renée M, Kapur Payal, Brugarolas James

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is characterized by BAP1 and PBRM1 mutations, which are associated with tumors of different grade and prognosis. However, whether BAP1 and PBRM1 loss causes ccRCC and determines tumor grade is unclear. We conditionally targeted Bap1 and Pbrm1 (with Vhl) in the mouse using several Cre drivers. Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis,...

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Source

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Identifiers

PMID: 28473526
DOI: 10.1158/2159-8290.CD-17-0292
PMCID: PMC5540776

Genes

BAP1
PBRM1
PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.PMID 28473526Read ↗

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