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Article

Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2017

Lu Yao Wei, Lowery Anthony M, Sun Li-Yan, Singer Harold A, Dai Guohao, Adam Alejandro P, Vincent Peter A, Schwarz John J

Abstract excerpt

OBJECTIVE: Laminar flow activates myocyte enhancer factor 2 (MEF2) transcription factors in vitro to induce expression of atheroprotective genes in the endothelium. Here we sought to establish the role of Mef2c in the vascular endothelium in vivo. APPROACH AND RESULTS: To study endothelial Mef2c, we generated endothelial-specific deletion of Mef2c using Tie2-Cre or Cdh5-Cre-ERT2 and examined aortas and carotid...

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Identifiers

PMID: 28473437
DOI: 10.1161/ATVBAHA.117.309180
PMCID: PMC5527298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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