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Article

Adventitial Sca1+ Cells Transduced With ETV2 Are Committed to the Endothelial Fate and Improve Vascular Remodeling After Injury.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2018

Le Bras Alexandra, Yu Baoqi, Issa Bhaloo Shirin, Hong Xuechong, Zhang Zhongyi, Hu Yanhua, Xu Qingbo

Abstract excerpt

OBJECTIVE: Vascular adventitial Sca1+ (stem cell antigen-1) progenitor cells preferentially differentiate into smooth muscle cells, which contribute to vascular remodeling and neointima formation in vessel grafts. Therefore, directing the differentiation of Sca1+ cells toward the endothelial lineage could represent a new therapeutic strategy against vascular disease. APPROACH AND RESULTS: We thus developed a...

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Source

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Identifiers

PMID: 29191922
DOI: 10.1161/ATVBAHA.117.309853
PMCID: PMC5757665

Genes

ETV2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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