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Article

Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation.

Biomedical research (Tokyo, Japan) - 1 Jan 2015

Uddin Mohammad Khaja Mafij, Kimura Wataru, Ishikura Tomoyuki, Koseki Haruhiko, Yoshida Nobuaki, Islam Mohammad Johirul, Amin Mohammed Badrul, Nakamura Kasumi, Wu Yi-Xin, Sato Eiji, Aoto Kazushi, Miura Naoyuki

Abstract excerpt

The forkhead box C2 (Foxc2) protein is a member of the forkhead/winged helix transcription factor family and plays an essential role in cardiovascular development. Previous studies showed that Foxc2 null mouse embryos die during midgestation or just after birth with severe cardiovascular defects, including interruption, coarctation of the aortic arch and ventricular septal defects. These are also seen in human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26299482
DOI: 10.2220/biomedres.36.235

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