GBA1 rs3115534 Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease in Nigerians.

doi:10.1002/mds.29753

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Article

GBA1 rs3115534 Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease in Nigerians.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2024

Ojo Oluwadamilola Omolara, Bandres-Ciga Sara, Makarious Mary B, Crea Peter Wild, Hernandez Dena G, Houlden Henry, Rizig Mie, Singleton Andrew B, Noyce Alastair J, Nalls Mike A, Blauwendraat Cornelis, Okubadejo Njideka Ulunma

Abstract excerpt

BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) is an early feature of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Damaging coding variants in Glucocerebrosidase (GBA1) are a genetic risk factor for RBD. Recently, a population-specific non-coding risk variant (rs3115534) was found to be associated with PD risk and earlier onset in individuals of African ancestry. OBJECTIVES:...

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PMID: 38390630
DOI: 10.1002/mds.29753
PMCID: PMC12164542

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GBA1

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