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Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology.

Molecular cancer therapeutics - 1 May 2017

Husain Hatim, Nykin David, Bui Nam, Quan Daniel, Gomez German, Woodward Brian, Venkatapathy Sumathi, Duttagupta Radha, Fung Eric, Lippman Scott M, Kurzrock Razelle

Abstract excerpt

Collection of cell-free DNA (cfDNA) from the blood of individuals with cancer has permitted noninvasive tumor genome analysis. Detection and characterization of cfDNA in ascites and pleural effusions have not yet been reported. Herein, we analyzed cfDNA in the ascites and pleural effusions from six individuals with metastatic cancer. In all cases, cfDNA copy number variations (CNV) were discovered within the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28468865
DOI: 10.1158/1535-7163.MCT-16-0436

Genes

CDK4
EGFR
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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