Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell-free DNA from ascites identifies clinically relevant variants and tumour evolution in patients with advanced ovarian cancer.

Molecular oncology - 1 Nov 2024

Werner Bonnita, Powell Elyse, Duggan Jennifer, Cortesi Marilisa, Lee Yeh Chen, Arora Vivek, Athavale Ramanand, Dean Michael, Warton Kristina, Ford Caroline E

Abstract excerpt

The emergence of targeted therapies has transformed ovarian cancer treatment. However, biomarker profiling for precision medicine is limited by access to quality, tumour-enriched tissue samples. The use of cell-free DNA (cfDNA) in ascites presents a potential solution to this challenge. In this study, next-generation sequencing was performed on ascites-derived cfDNA samples (26 samples from 15 human participants...

Topics

Join the communities discussing this publication.

Aged
Ascites
Biomarkers, Tumor
Cell-Free Nucleic Acids
DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

Loss of Heterozygosity

Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 39115191
DOI: 10.1002/1878-0261.13710
PMCID: PMC11547227

Genes

BRCA1
BRCA2
MYC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell-free DNA from ascites identifies clinically relevant variants and tumour evolution in patients with advanced ovarian cancer.PMID 39115191Read ↗

Cell-free DNA from ascites identifies clinically relevant variants and tumour evolution in patients with advanced ovarian cancerSemantic proximity Read ↗

Assessing the Concordance of Genomic Alterations between Circulating-Free DNA and Tumour Tissue in Cancer PatientsSemantic proximity Read ↗

Exploring alternatives to tumor tissue for BRCA1/2 next-generation sequencing testing in high-grade serous ovarian cancer: A 34-case series of malignant ascites.Semantic proximity Read ↗

Concordance of Genomic Alterations in Ovarian Cancer Tissues and Circulating-Tumor DNA: A Pilot Study.Semantic proximity Read ↗

Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid.Semantic proximity Read ↗

Current Applications and Challenges of Next-Generation Sequencing in Plasma Circulating Tumour DNA of Ovarian CancerSemantic proximity Read ↗

Cell-Free DNA, Tumor Molecular Concordance, and Clinical Correlates of Patients with Cancer Treated in a Large Community Health Care NetworkSemantic proximity Read ↗

Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology.Semantic proximity Read ↗

Serial Circulating Tumor DNA Analysis with a Tumor-Naïve Next-Generation Sequencing Panel Detects Minimal Residual Disease and Predicts Outcome in Ovarian Cancer.Semantic proximity Read ↗

Targeted deep sequencing revealed variants in cell-free DNA of hormone receptor-positive metastatic breast cancer patientsSemantic proximity Read ↗

Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.Semantic proximity Read ↗

Circulating cell-free DNA and circulating tumor cells, the "liquid biopsies" in ovarian cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.