Article
Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control.
Retrovirology - 10 Sept 2018
Caetano Diogo Gama, Côrtes Fernanda Heloise, Bello Gonzalo, Teixeira Sylvia Lopes Maia, Hoagland Brenda, Grinsztejn Beatriz, Veloso Valdilea Gonçalves, Guimarães Monick Lindenmeyer, Morgado Mariza Gonçalves
Abstract excerpt
BACKGROUND: Despite the low level of viral replication in HIV controllers (HICs), studies have reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in HIV-1 plasma sequences. Thus, evaluating the dynamics of the emergence of CTL-escape mutants in HICs reservoirs is important for understanding viremia control. To analyze the HIV-1 mutational profile and dynamics of CTL-escape...
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