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Article

Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-γ+ Response Driven by Urban Particulate Matter.

American journal of respiratory cell and molecular biology - 1 Sept 2017

Mann Elizabeth H, Ho Tzer-Ren, Pfeffer Paul E, Matthews Nick C, Chevretton Elfy, Mudway Ian, Kelly Frank J, Hawrylowicz Catherine M

Abstract excerpt

Urban particulate matter (UPM) air pollution and vitamin D deficiency are detrimentally associated with respiratory health. This is hypothesized to be due in part to regulation of IL-17A, which UPM is reported to promote. Here, we used a myeloid dendritic cell (DC)-memory CD4+ T cell co-culture system to characterize UPM-driven IL-17A+ cells, investigate the mechanism by which UPM-primed DCs promote this...

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Identifiers

PMID: 28463086
DOI: 10.1165/rcmb.2016-0409OC
PMCID: PMC5625227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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