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Article

Urban Particulate Matter-Activated Human Dendritic Cells Induce the Expansion of Potent Inflammatory Th1, Th2, and Th17 Effector Cells.

American journal of respiratory cell and molecular biology - 1 Feb 2016

Matthews Nick C, Pfeffer Paul E, Mann Elizabeth H, Kelly Frank J, Corrigan Christopher J, Hawrylowicz Catherine M, Lee Tak H

Abstract excerpt

Exposure to urban particulate matter (UPM) exacerbates asthmatic lung inflammation. Lung dendritic cells (DCs) are critical for stimulating T cell immunity and in maintaining airway tolerance, but they also react to airway UPM. The adjuvant role of UPM in enhancing primary immune responses by naive cells to allergen has been reported, but the direct effects of UPM-activated DCs on the functionality of human...

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Identifiers

PMID: 26196219
DOI: 10.1165/rcmb.2015-0084OC
PMCID: PMC4821044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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