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Oxidative Stress and PRKN-Mediated Senescence Link RhoA/ROCK Signaling to Epithelial Remodeling in Allergic Rhinitis

2025-12-02

Abstract excerpt

Allergic rhinitis (AR) is characterized by persistent epithelial remodeling, yet the upstream drivers and molecular mechanisms remain poorly defined. Analysis of nasal mucosa from AR patients revealed marked epithelial remodeling, oxidative stress, and Th2 inflammation. Transcriptome analysis of nasal mucosa revealed RhoA as one of the most upregulated genes, with expression positively correlating with disease sev...

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Literature Corpus work
6eb29c47-f00d-5edb-b237-749e1cc5c2bd
DOI
10.20944/preprints202512.0299.v1
Open publication

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Oxidative Stress and PRKN-Mediated Senescence Link RhoA/ROCK Signaling to Epithelial Remodeling in Allergic RhinitisDOI 10.20944/preprints202512.0299.v1
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