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Article

Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis.

Brain : a journal of neurology - 2 May 2023

Seyedsalehi Aida, Warrier Varun, Bethlehem Richard A I, Perry Benjamin I, Burgess Stephen, Murray Graham K

Abstract excerpt

Higher educational attainment is observationally associated with lower risk of Alzheimer's disease. However, the biological mechanisms underpinning this association remain unclear. The protective effect of education on Alzheimer's disease may be mediated via increased brain reserve. We used two-sample Mendelian randomization to explore putative causal relationships between educational attainment, structural brain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36310536
DOI: 10.1093/brain/awac392
PMCID: PMC10151197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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