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Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori.

Cytokine - 1 Aug 2017

Melchiades Jessica L, Zabaglia Luanna M, Sallas Mayara L, Orcini Wilson A, Chen Elizabeth, Smith Marilia A C, Payão Spencer L M, Rasmussen Lucas T

Abstract excerpt

Interleukin 2 (IL-2) is a pro-inflammatory cytokine that is mainly synthesized by immunoregulatory T helper cells and which plays an important role in antitumor immunity. Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the gastric mucosa and induces the production of IL-2. This process increases the magnitude of inflammation and may influence the development of gastric pathologies. In...

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PMID: 28458166
DOI: 10.1016/j.cyto.2017.04.020

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