Article
Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects.
Journal of gastroenterology and hepatology - 1 Sept 2007
Sugimoto Mitsushige, Furuta Takahisa, Shirai Naohito, Nakamura Akiko, Kajimura Masayoshi, Sugimura Haruhiko, Hishida Akira
Abstract excerpt
BACKGROUND: Anti-inflammatory cytokines play an important role in downregulation of inflammation and the prevention of neoplastic disorders. Genetic variations of anti-inflammatory cytokines are assumed to influence such responses. The aim of the present study was to clarify the association between the IL-10 polymorphism, one of the representative anti-inflammatory cytokines, and susceptibility to gastric cancer...
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