Article
Polymorphisms in POLG were associated with the prognosis and mtDNA content in hepatocellular carcinoma patients.
Bulletin du cancer - 1 Jun 2017
Long Xiaoyu, Wang Xiaoyan, Chen Yibing, Guo Xu, Zhou Feng, Fan Yongguo, Ge Naijian, Guo Mei, Zhang Zhaohui, Dong Guanglong
Abstract excerpt
BACKGROUND: POLG is a gene that codes for the catalytic subunit of the mitochondrial DNA polymerase, which is involved in the replication of mitochondrial DNA. Genetic variants in mitochondrial DNA polymerase-γ (POLG) have been associated with several malignancies. However, as an important metabolic tissue, association between genetic polymorphisms of POLG and the prognosis and mitochondrial DNA (mtDNA) content...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.