Article
Genomic signatures of drug resistance in highly resistant Mycobacterium tuberculosis strains of the early ancient sublineage of Beijing genotype in Russia.
International journal of antimicrobial agents - 1 Aug 2020
Mokrousov Igor, Sinkov Viacheslav, Vyazovaya Anna, Pasechnik Oksana, Solovieva Natalia, Khromova Polina, Zhuravlev Viacheslav, Ogarkov Oleg
Abstract excerpt
The Mycobacterium tuberculosis Beijing genotype is a clinically and epidemiologically important lineage that is subdivided into ancient/ancestral and modern strains. In our previous study in western Siberia, we identified variable number of tandem repeats (VNTR)-based clusters within the early ancient sublineage of the Beijing genotype characterized by an unexpectedly high rate of extensive drug resistance (XDR)....
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