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Association between polymorphisms in TP53 and MDM2 genes and susceptibility to prostate cancer

14 Feb 2017

Abstract excerpt

Tumor protein 53 (TP53), a tumor suppressor gene, is a vital cellular cancer suppressor in multicellular organisms. Murine double minute-2 (MDM2) is an oncoprotein that inhibits TP53 activity. A number of studies have examined the association of TP53 and MDM2 polymorphisms with the risk of common forms of cancer, but the findings remain inconclusive. The present study aimed to evaluate the impact of the 40‑bp...

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PMID: 28454424
DOI: 10.3892/ol.2017.5739

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