Human mesenchymal stem cells maintain their phenotype, multipotentiality, and genetic stability when cultured using a defined xeno-free human plasma fraction.

doi:10.1186/s13287-017-0552-z

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Article

Human mesenchymal stem cells maintain their phenotype, multipotentiality, and genetic stability when cultured using a defined xeno-free human plasma fraction.

Stem cell research & therapy - 27 Apr 2017

Blázquez-Prunera Arantxa, Díez José María, Gajardo Rodrigo, Grancha Salvador

Abstract excerpt

BACKGROUND: Mesenchymal stem cells (MSCs) show promising characteristics for their use in advanced therapy medicinal products. However, there are some unresolved concerns, such as the use of animal components for their expansion. In this study we assessed the suitability of a xeno-free supplement for cell culture (SCC) derived from human plasma, to culture and expand human MSCs (hMSCs) from different origins....

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PMID: 28449711
DOI: 10.1186/s13287-017-0552-z
PMCID: PMC5408419

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