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A Defined and Xeno-Free Culture Method Enabling the Establishment of Clinical-Grade Human Embryonic, Induced Pluripotent and Adipose Stem Cells

19 Apr 2010

Abstract excerpt

BACKGROUND: The growth of stem cells in in vitro conditions requires optimal balance between signals mediating cell survival, proliferation, and self-renewal. For clinical application of stem cells, the use of completely defined conditions and elimination of all animal-derived materials from the establishment, culture, and differentiation processes is desirable. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report the...

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PMID: 20419109
DOI: 10.1371/journal.pone.0010246

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