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Article

Cell cycle-dependent regulation of Greatwall kinase by protein phosphatase 1 and regulatory subunit 3B.

The Journal of biological chemistry - 16 Jun 2017

Ren Dapeng, Fisher Laura A, Zhao Jing, Wang Ling, Williams Byron C, Goldberg Michael L, Peng Aimin

Abstract excerpt

Greatwall (Gwl) kinase plays an essential role in the regulation of mitotic entry and progression. Mitotic activation of Gwl requires both cyclin-dependent kinase 1 (CDK1)-dependent phosphorylation and its autophosphorylation at an evolutionarily conserved serine residue near the carboxyl terminus (Ser-883 in Xenopus). In this study we show that Gwl associates with protein phosphatase 1 (PP1), particularly PP1γ,...

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Share to Cyclin-Dependent Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28446604
DOI: 10.1074/jbc.M117.778233
PMCID: PMC5473210

Genes

CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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