Article
Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis.
PLoS genetics - 1 Aug 2011
Rangone Hélène, Wegel Eva, Gatt Melanie K, Yeung Eirene, Flowers Alexander, Debski Janusz, Dadlez Michal, Janssens Veerle, Carpenter Adelaide T C, Glover David M
Abstract excerpt
Protein phosphatase 2A (PP2A) plays a major role in dephosphorylating the targets of the major mitotic kinase Cdk1 at mitotic exit, yet how it is regulated in mitotic progression is poorly understood. Here we show that mutations in either the catalytic or regulatory twins/B55 subunit of PP2A act as enhancers of gwl(Scant), a gain-of-function allele of the Greatwall kinase gene that leads to embryonic lethality in...
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