Article

The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

2025-06-03

Abstract excerpt

The Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understanding of cellular and molecular consequences of chemical Greatwall inactivation remains limited. To address this, we introduce C-604, a highly selective Greatwall inhibitor, and charac...

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Identifiers and source

Literature Corpus work: bef44201-10b5-51d1-ba21-2a9add041dcf
DOI: 10.1101/2025.06.02.657035

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