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Article

Characterization of the mechanisms controlling Greatwall activity.

Molecular and cellular biology - 1 Jun 2011

Vigneron Suzanne, Gharbi-Ayachi Aicha, Raymond Anne-Aurélie, Burgess Andrew, Labbé Jean-Claude, Labesse Gilles, Monsarrat Bernard, Lorca Thierry, Castro Anna

Abstract excerpt

Here we investigate the mechanisms regulating Greatwall (Gwl), a serine/threonine kinase essential for promoting the correct timing of mitosis. We identify Gwl as a unique AGC kinase that, unlike most AGC members, appears to be devoid of a hydrophobic motif despite the presence of a functional hydrophobic pocket. Our results suggest that Gwl activation could be mediated by the binding of its hydrophobic pocket to...

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Identifiers

PMID: 21444715
DOI: 10.1128/MCB.00753-10
PMCID: PMC3133244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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