Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci.

Nature genetics - 1 Jun 2017

Stender Stefan, Kozlitina Julia, Nordestgaard Børge G, Tybjærg-Hansen Anne, Hobbs Helen H, Cohen Jonathan C

Abstract excerpt

Complex traits arise from the interplay between genetic and environmental factors. The actions of these factors usually appear to be additive, and few compelling examples of gene-environment synergy have been documented. Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Adiposity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alanine Transaminase

Share to Cohort Studies

Share to Lipase

Share to Membrane Proteins

Share to Non-alcoholic Fatty Liver Disease

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 28436986
DOI: 10.1038/ng.3855
PMCID: PMC5562020

Genes

GCKR
PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci.PMID 28436986Read ↗

Update on NAFLD genetics: From new variants to the clinic.Semantic proximity Read ↗

Genetic modulators of metabolic dysfunction-associated steatotic liver disease (MASLD) and their epistatic interactions: from in vitro and animal models to clinical outcomes.Semantic proximity Read ↗

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology.Semantic proximity Read ↗

Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.Semantic proximity Read ↗

Genetic Variations and Nonalcoholic Fatty Liver Disease: Field Synopsis, Systematic Meta-Analysis, and Epidemiological Evidence.Semantic proximity Read ↗

Genetic risk amplifies lifestyle effects on hepatic steatosis and its progression: Insights from a population-based cohort.Semantic proximity Read ↗

Association of genetic variations with NAFLD in lean individuals.Semantic proximity Read ↗

Host genetic variants in obesity-related nonalcoholic fatty liver disease.Semantic proximity Read ↗

Additive effects of PNPLA3 and TM6SF2 on the histological severity of non-alcoholic fatty liver disease.Semantic proximity Read ↗

The additive effect of genetic and metabolic factors in the pathogenesis of nonalcoholic fatty liver diseaseSemantic proximity Read ↗

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects.Semantic proximity Read ↗

Fish intake interacts with TM6SF2 gene variant to affect NAFLD risk: results of a case-control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.