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The additive effect of genetic and metabolic factors in the pathogenesis of nonalcoholic fatty liver disease

20 Oct 2022

Abstract excerpt

Abstract Both genetic and metabolic factors influence the pathology of nonalcoholic fatty liver disease (NAFLD). The aim of this retrospective study was to evaluate the impact of these factors at each stage of disease. We analysed the impact of obesity, diabetes mellitus and genetic risk factors (alleles ofPNPLA3orHSD17B13) on nonalcoholic steatohepatitis (NASH), significant fibrosis (stage ≥ 2) and advanced...

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PMID: 36266438
DOI: 10.1038/s41598-022-22729-5

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