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Article

Altered sleep patterns in patients with non-functional GHRH receptor.

European journal of endocrinology - 1 Jul 2017

Oliveira Francielle T, Salvatori Roberto, Marcondes José, Macena Larissa B, Oliveira-Santos Alecia A, Faro Augusto C N, Campos Viviane C, Oliveira Carla R P, Costa Ursula M M, Aguiar-Oliveira Manuel H

Abstract excerpt

OBJECTIVES: GH-releasing hormone (GHRH) exerts hypnotic actions increasing the non-rapid eye movement (NREM) sleep. Conversely, GH stimulates the REM sleep. GH deficiency (GHD) often leads to sleep problems, daytime fatigue and reduced quality of life (QoL). GHD may be due to lack of hypothalamic GHRH or destruction of somatotroph cells. We have described a cohort with isolated GHD (IGHD) due to GHRH resistance...

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Source

Identifiers

PMID: 28432269
DOI: 10.1530/EJE-17-0145

Genes

GHRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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