Article
Individuals with isolated congenital GH deficiency due to a GHRH receptor gene mutation appear to cope better with SARS-CoV-2 infection than controls.
Endocrine - 1 May 2021
Melo Manuela A, Borges Lysandro P, Salvatori Roberto, Souza Daniela R V, Santos-Júnior Hertz T, de R Neto José M, Campos Viviane C, Santos Aryanne A, Oliveira Carla R P, da Invenção Grazielly B, Batista Vanderlan O, Matos Igor L S, Barros-Oliveira Cynthia S, Dos Santos Kezia A, Santos Elenilde G, Souza Nicolas A A, Melo Enaldo V, Borges Pamela C, Santos Saulo E F S, de Oliveira Brenda M, Oliveira-Santos Alécia A, de Jesus Amélia R, Aguiar-Oliveira Manuel H
Abstract excerpt
PURPOSE: Several interactions exist between the GH/IGF axis and the immune system, including effects on innate immunity and humoral and cellular response. Acquired GH deficiency (GHD) has been recently proposed as a risk factor for severity of COVID-19 infections. However, acquired GHD is often associated to other factors, including pituitary tumors, surgery, radiotherapy, and additional pituitary hormones...
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