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Article

Magnetic resonance imaging study of pituitary morphology in subjects homozygous and heterozygous for a null mutation of the GHRH receptor gene.

European journal of endocrinology - 1 Apr 2003

Oliveira Helio A, Salvatori Roberto, Krauss Miriam P O, Oliveira Carla R P, Silva Paula R C, Aguiar-Oliveira Manuel H

Abstract excerpt

OBJECTIVE: Somatotrophs represent the majority of cells in the anterior pituitary, and their numeric reduction can cause anterior pituitary hypoplasia (APH). Small numbers of patients with familial isolated GH deficiency (IGHD) due to bi-allelic mutations in the GHRH receptor (GHRHR) gene (GHRHR) have been reported to have APH. We tested if APH was present in a large cohort of patients homozygous and heterozygous...

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Source

Identifiers

PMID: 12656663
DOI: 10.1530/eje.0.1480427

Genes

GHRHR
GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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