Article
Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses.
The Journal of clinical endocrinology and metabolism - 1 Jun 2001
Roelfsema F, Biermasz N R, Veldman R G, Veldhuis J D, Frölich M, Stokvis-Brantsma W H, Wit J M
Abstract excerpt
GH secretion is regulated by the interaction of GHRH and somatostatin and is released in 10-20 pulses in each 24-h cycle. The exact roles in pulse generation played by somatostatin, GHRH, and the recently isolated GH-releasing peptide, Ghrelin, are not fully elucidated. To investigate the GHRH-mediated GH secretion in human, we investigated pulsatile, entropic, and 24-h rhythmic GH secretion in two young adults...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.