Article
Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate.
Molecular cell - 20 Apr 2017
Yeom Jinki, Wayne Kyle J, Groisman Eduardo A
Abstract excerpt
According to the N-end rule, the N-terminal residue of a protein determines its stability. In bacteria, the adaptor ClpS mediates proteolysis by delivering substrates bearing specific N-terminal residues to the protease ClpAP. We now report that the Salmonella adaptor ClpS binds to the N terminus of the regulatory protein PhoP, resulting in PhoP degradation by ClpAP. We establish that the PhoP-activated protein...
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