Article
Angiotensin-converting enzyme insertion/deletion gene polymorphism and interferon-β treatment response in multiple sclerosis patients: a preliminary report.
Pharmacogenetics and genomics - 1 Jun 2017
Ristić Smiljana, Starčević Čizmarević Nada, Lavtar Polona, Lovrečić Luca, Perković Olivio, Sepčić Juraj, Šega Jazbec Saša, Kapović Miljenko, Peterlin Borut
Abstract excerpt
We investigated the effect of the functional insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene on the response to interferon-β (IFN-β) therapy in Croatian and Slovenian patients with multiple sclerosis (MS). A total of 275 IFN-β treated MS patients [162 responders (Rs) and 113 nonresponders (NRs)] were genotyped by PCR. The ACE I/D genotype distribution and allele frequencies...
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