Article
CCR5 Δ32 and CTLA-4 +49 A/G Gene Polymorphisms and Interferon-β Treatment Response in Croatian and Slovenian Multiple Sclerosis Patients.
International journal of molecular sciences - 5 Jul 2024
Nekić Jasna, Stanković Matić Ivana, Rački Valentino, Janko Labinac Dolores, Vuletić Vladimira, Kapović Miljenko, Ristić Smiljana, Peterlin Borut, Starčević Čizmarević Nada
Abstract excerpt
The aim of the present study was to investigate the impact of CCR5 Δ32 and CTLA-4 polymorphisms on the response to IFN-β treatment in our cohort of MS patients from Croatia and Slovenia. Genomic DNA was obtained from 295 MS patients (230 female; 65 male) classified as responders (n = 173) and non-responders (n = 122) based on clinical criteria for treatment efficacy. Genotyping was performed via PCR/PCR-RFLP. No...
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