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Article

Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin

5 May 2016

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial DNA. Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene, is an E3 ubiquitin ligase crucial for mitophagy. Although DNA damage is known to induce mitochondrial stress, Parkin's role in regulating DNA repair proteins has not been...

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PMID: 27148961
DOI: 10.1002/mc.22495

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